Geno2pheno: interpreting genotypic HIV drug resistance tests
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چکیده
منابع مشابه
Geno2pheno: Interpreting Genotypic HIV Drug Resistance Tests
nonnucleoside reverse transcriptase (RT) inhibitors (NRTI and NNRTI, respectively) and protease inhibitors (PI). (See the “Abbreviations” sidebar for other abbreviations in this article). Even with the currently recommended combination therapies consisting of three to five drugs, few patients achieve longterm suppression of plasma virus levels below detectable limits. Drug resistance1 is a majo...
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Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for protease and reverse transcriptase, the molecular targets of current antiretroviral therapy. Genotypic resistance testing depends on the ability to interpret such sequence data, whereas phenotypic resista...
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MOTIVATION Human immunodeficiency virus type 1 (HIV-1) evolves in human body, and its exposure to a drug often causes mutations that enhance the resistance against the drug. To design an effective pharmacotherapy for an individual patient, it is important to accurately predict the drug resistance based on genotype data. Notably, the resistance is not just the simple sum of the effects of all mu...
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Interpreting the results of drug resistance tests for HIV-1 is one of the most difficult tasks for both clinicians and virologists. There are many amino acid changes in viral proteins influencing the susceptibility to specific drugs, causing loss of activity or conversely hypersusceptibility. Moreover, the results of interactions derived from complex mutational patterns are difficult to predict...
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UNLABELLED The calibrated population resistance (CPR) tool is a web-accessible program for performing standardized genotypic estimation of transmitted HIV-1 drug resistance. The program is linked to the Stanford HIV drug resistance database and can additionally perform viral genotyping and algorithmic estimation of resistance to specific antiretroviral drugs. AVAILABILITY http://cpr.stanford....
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ژورنال
عنوان ژورنال: IEEE Intelligent Systems
سال: 2001
ISSN: 1541-1672,1941-1294
DOI: 10.1109/5254.972080